The Quadruple Marker Test is a second-trimester prenatal screening test that measures four specific substances in the mother’s blood. It helps assess the risk of chromosomal abnormalities and neural tube defects in the fetus.
Purpose of the Test:
•Screen for chromosomal abnormalities: Detects the likelihood of conditions like Down syndrome (Trisomy 21), Edwards syndrome (Trisomy 18), and Turner syndrome.
•Detect neural tube defects: Identifies conditions like spina bifida or anencephaly.
•Assess pregnancy health: Provides information about fetal and placental health.
Components of the Test:
1.Alpha-Fetoprotein (AFP): A protein made by the fetus; abnormal levels can indicate neural tube defects or chromosomal abnormalities.
2.Human Chorionic Gonadotropin (hCG): A hormone produced by the placenta; abnormal levels suggest potential chromosomal conditions.
3.Unconjugated Estriol (uE3): A hormone made by the placenta and fetal liver; low levels may indicate placental or chromosomal issues.
4.Inhibin A: A hormone produced by the placenta; elevated levels may indicate chromosomal abnormalities like Down syndrome.
Key Notes:
•Performed between 15 to 20 weeks of pregnancy.
•It is a screening test, not diagnostic, meaning it provides a risk assessment rather than a definitive diagnosis.
•Abnormal results may require additional tests
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