The Dual Marker or Double Marker Test is a prenatal screening test performed during the first trimester of pregnancy. It evaluates the levels of two hormones/proteins in the mother’s blood to assess the risk of chromosomal abnormalities in the fetus, such as Down syndrome (Trisomy 21), Edwards syndrome (Trisomy 18), or other genetic disorders.
Purpose of the Test:
•Screen for chromosomal abnormalities: Identifies the likelihood of genetic conditions in the fetus.
•Evaluate pregnancy health: Provides insights into potential complications or risks.
•Determine the need for further testing: Helps decide if more advanced diagnostic procedures like amniocentesis or chorionic villus sampling (CVS) are required.
Components of the Test:
1.Free Beta-hCG (Human Chorionic Gonadotropin): A hormone produced during pregnancy; abnormal levels can indicate chromosomal abnormalities.
2.PAPP-A (Pregnancy-Associated Plasma Protein A): A protein produced by the placenta; altered levels may suggest chromosomal or placental issues.
Key Notes:
•Performed between 10 to 14 weeks of pregnancy as part of first-trimester screening.
•Often combined with ultrasound for nuchal translucency (NT) to enhance accuracy.
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