The Creatine Kinase MB (CK-MB) test measures the level of the CK-MB isoenzyme in the blood. CK-MB is primarily found in the heart muscles and is released into the bloodstream when heart muscle damage occurs, making this test a key marker for diagnosing and monitoring heart conditions.
Purpose of the Test:
•Diagnose heart attack (myocardial infarction): Detects damage to heart muscles in the early stages.
•Monitor heart conditions: Tracks ongoing cardiac events or the effectiveness of treatment.
•Differentiate heart from skeletal muscle damage: CK-MB is more specific to the heart compared to total CK levels.
Conditions Indicated by Elevated Levels:
•Acute myocardial infarction (heart attack)
•Myocarditis (inflammation of the heart muscles)
•Cardiac trauma or injury, such as after surgery or an accident
•Severe muscle diseases, although CK-MB levels are less commonly elevated in skeletal muscle disorders.
Key Notes:
•CK-MB levels typically rise 3–6 hours after a heart attack, peak at 12–24 hours, and return to normal within 48–72 hours.
•This test is often performed alongside troponin tests, which are more specific for heart damage.
•Elevated CK-MB levels should be correlated with clinical findings and other cardiac markers for accurate diagnosis.
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